L-Homopropargylglycine

L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

Product Specifications

CAS Number

[98891-36-2]

UNSPSC

12352211

Hazard Statement

H242

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-homopropargylglycine.html

Purity

98.0

Solubility

H2O : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C#CCC[C@H](N)C(O)=O

Molecular Formula

C6H9NO2

Molecular Weight

127.14

Precautions

H242

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562|[2]Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2 (3) :100616. Published 2021 Jun 17.