Methyl syringate

Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis[1][2][3][4].

Product Specifications

CAS Number

[884-35-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; COX; Phosphatase; TRP Channel

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/methyl-syringate.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC)C1=CC(OC)=C(O)C(OC)=C1

Molecular Formula

C10H12O5

Molecular Weight

212.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Tuberoso CI, et al. Methyl syringate: a chemical marker of asphodel (Asphodelus microcarpus Salzm. et Viv.) monofloral honey. J Agric Food Chem. 2009 May 13;57 (9) :3895-900.|[2]Rosado T, et al. Methyl syringate: an efficient phenolic mediator for bacterial and fungal laccases. Bioresour Technol. 2012 Nov;124:371-8.|[3]Kim MJ, et al. The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. PLoS One. 2013 Aug 21;8 (8) :e71603.|[4]Joonwoo Park, et al., Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells, Phytomedicine, Volume 23, Issue 3, 2016, Pages 324-329, ISSN 0944-7113.|[5]Ahn D, et al., Methyl Syringate Stimulates Glucose Uptake by Inhibiting Protein Tyrosine Phosphatases Relevant to Insulin Resistance. Life. 2023; 13 (6) :1372.