Fmoc-VAP-MMAE
Fmoc-VAP-MMAE is a agent-linker conjugates for ADC. Fmoc-VAP-MMAE consists of an ADC linker and a tubulin inhibitor MMAE (HY-15162), with a protective Fmoc group[1].
Product Specifications
CAS Number
[1912408-91-3]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/fmoc-vap-mmae.html
Purity
99.00
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@H](C(C)C)NC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O)=O)=O)=O)=O)=O
Molecular Formula
C70H98N8O13
Molecular Weight
1259.57
References & Citations
[1]Jackson David Y et al. Novel antibody-drug conjugates and related compounds, compositions, and methods of use. Patent. WO2016064749.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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SERCA1 (ATP2A1, ATPase, Ca++ transporting, Cardiac Muscle, Fast Twitch 1, ATP2A, OTTHUMP00000162562, SR Ca (2+) -ATPase 1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum Type, Fast Twitch skeletal Muscle isoform, Endoplasmic reticulum class 1/2 Ca (2+) ATPase, Sarcoplasmic/endoplasm)
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