Taccalonolide AJ
Product Specifications
UNSPSC Description
Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells[1].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taccalonolide-aj.html
Purity
98.0
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
C[C@]1([C@@]2(O)C)[C@]3(OC2=O)[C@H]([C@@H](C)[C@@]4([H])[C@@]1([H])[C@@H]([C@]5([H])[C@@]4([C@H]([C@@H](OC(C)=O)[C@@]6([H])[C@@]5([H])[C@H](C([C@]7([H])[C@@]6([C@H]([C@@H](O8)[C@@H]8C7)OC(C)=O)C)=O)O)OC(C)=O)C)O)O3
Molecular Weight
676.70
References & Citations
[1]Li J, et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc. 2011 Nov 30;133(47):19064-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N4208/Taccalonolide-AJ-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N4208/Taccalonolide-AJ-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2230777-09-8
Available Sizes
Curated Selection
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