QN523

QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer[1].

Product Specifications

CAS Number

[878581-60-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Apoptosis; Autophagy

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/qn523.html

Purity

99.77

Solubility

DMSO : ≥ 16.67 mg/mL

Smiles

O=C(C1=NC=CN=C1)NC2=CC=CC3=CC=CN=C32

Molecular Formula

C14H10N4O

Molecular Weight

250.26

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Kuang Y, et, al. Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer. J Med Chem. 2022 Apr 28;65 (8) :6133-6156.|[2]Kuang Y, et, al. Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer. J Med Chem. 2022 Apr 28;65 (8) :6133-6156.