Kushenol X

Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].

Product Specifications

CAS Number

[254886-77-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Carboxylesterase (CES) ; β-glucuronidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/kushenol-x.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

CC([C@H](C/C=C(C)/C)CC(C(O)=C1)=C(O[C@H](C(C=CC(O)=C2)=C2O)[C@H]3O)C(C3=O)=C1O)=C

Molecular Formula

C25H28O7

Molecular Weight

440.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358.|[2]Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208.