Diazinon

Diazinon is an orally active, irreversible AChE inhibitor and insecticide that can be absorbed through the digestive system, skin or respiratory tract. Diazinon inhibits AChE, leading to accumulation of acetylcholine, which in turn overstimulates ACh receptors and affects the nervous system. Diazinon also produces reactive oxygen species (ROS), which induce oxidative stress in various tissues. Diazinon is mainly used in the agricultural field as an insecticide and may have potential effects on human and animal health[1][2][3][4].

Product Specifications

CAS Number

[333-41-5]

Product Name Alternative

Dimpylate

UNSPSC

12352005

Hazard Statement

H301-H350-H410

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Diazinon.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=P(OCC)(OCC)OC1=NC(C(C)C)=NC(C)=C1

Molecular Formula

C12H21N2O3PS

Molecular Weight

304.35

Precautions

P264-P270-P273-P280-P330-P391-P405-P501

References & Citations

[1]Girón-Pérez MI, et al. Diazinon toxicity in hepatic and spleen mononuclear cells is associated to early induction of oxidative stress. Int J Environ Health Res. 2022 Oct;32 (10) :2309-2323.|[2]Zein MA, et al. Toxic effects of combined stressors on Daphnia pulex: Interactions between diazinon, 4-nonylphenol, and wastewater effluent. Environ Toxicol Chem. 2015 May;34 (5) :1145-53.|[3]Shah MD, et al. Diazinon-induced oxidative stress and renal dysfunction in rats. Food Chem Toxicol. 2010 Dec;48 (12) :3345-53.|[4]Neishabouri EZ, et al. Evaluation of immunotoxicity induced by diazinon in C57bl/6 mice. Toxicology. 2004 Mar 15;196 (3) :173-9.