Nrf2 activator-12
Nrf2 activator-12 (compund 10v) potently activates Nrf2 (EC50=83.5 nM) and exhibits promising pharmacological properties, reversing disease progression and alleviating demyelination in an experimental autoimmune encephalomyelitis mouse model[1].
Product Specifications
CAS Number
3020661-05-3
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-12.html
Purity
98.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=CN=C1S(=N)(/C=C/C2=CC=CC=C2Cl)=O
Molecular Formula
C13H10Cl2N2OS
Molecular Weight
313.20
References & Citations
[1]Kim Y, et al. Discovery and Optimization of a Series of Vinyl Sulfoximine-Based Analogues as Potent Nrf2 Activators for the Treatment of Multiple Sclerosis. J Med Chem. 2024 Oct 10;67 (19) :17866-17892.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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