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Nrf2 activator-12

Nrf2 activator-12 (compund 10v) potently activates Nrf2 (EC50=83.5 nM) and exhibits promising pharmacological properties, reversing disease progression and alleviating demyelination in an experimental autoimmune encephalomyelitis mouse model[1].

Product Specifications

CAS Number

3020661-05-3

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nrf2-activator-12.html

Purity

98.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=CN=C1S(=N)(/C=C/C2=CC=CC=C2Cl)=O

Molecular Formula

C13H10Cl2N2OS

Molecular Weight

313.20

References & Citations

[1]Kim Y, et al. Discovery and Optimization of a Series of Vinyl Sulfoximine-Based Analogues as Potent Nrf2 Activators for the Treatment of Multiple Sclerosis. J Med Chem. 2024 Oct 10;67 (19) :17866-17892.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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