3289-8625

3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM) . 3289-8625 can be used in the study of embryonic development and cancer[1].

Product Specifications

CAS Number

[294891-81-9]

UNSPSC

12352005

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3289-8625.html

Purity

99.19

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC=C1NC(C2=CC=CC(NC(CC3=CC=CC=C3)=O)=C2)=O

Molecular Formula

C22H18N2O4

Molecular Weight

374.39

References & Citations

[1]Grandy D, et al. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled[J]. Journal of Biological Chemistry, 2009, 284 (24) : 16256-16263.