L189
L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer[1][2].
Product Specifications
CAS Number
64232-83-3
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L189.html
Purity
98.0
Solubility
DMSO : ≥ 33 mg/mL
Smiles
OC1=NC(S)=NC(N)=C1/N=C/C2=CC=CC=C2
Molecular Formula
C11H10N4OS
Molecular Weight
246.29
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9) . May 1, 2008|[2]Devashree Jahagirdar, et al. Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa. Current Cancer Therapy Reviews, 2018, 14, 1-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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