Clopidogrel thiolactone

Clopidogrel thiolactone is an important intermediate in the metabolism of Clopidogrel (HY-15283) . Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects[1][2].

Product Specifications

CAS Number

[1147350-75-1]

UNSPSC

12352005

Target

Drug Metabolite; P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Clopidogrel-thiolactone.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 5 mg/mL (ultrasonic; warming; heat to 40°C)

Smiles

O=C(OC)[C@@H](N1CCC(S2)C(C1)=CC2=O)C3=C(Cl)C=CC=C3

Molecular Formula

C16H16ClNO3S

Molecular Weight

337.82

References & Citations

[1]Shan J, et, al. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent. J Med Chem. 2012 Apr 12;55 (7) :3342-52.|[2]Hagihara K, et, al. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs. Xenobiotica. 2009 Mar;39 (3) :218-26.