PROTAC α-synuclein degrader 3

PROTAC α-synuclein degrader 3 (Compound 5) is a selective α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 can promote the ubiquitination and degradation of α-synuclein. PROTAC α-synuclein degrader 3 can be used for Parkinson's disease research (Pink: target protein ligand (HY-W278021) ; Black: linker; HY-133302; Blue: E3 ligase VHL ligand (HY-112078) ) [1].

Product Specifications

CAS Number

[2412273-77-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTACs; α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling; PROTAC

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/protac-α-synuclein-degrader-3.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CNC(C=C1)=CC=C1C2=NC3=C(S2)C=C(OCCOCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)C=C3

Molecular Formula

C51H68N6O11S2

Molecular Weight

1005.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Andrew PC, et, al. Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases. WO2020041331A1.