15-Deoxy-Δ12,14-prostaglandin A1
Product Specifications
Product Name Alternative
SC-39026; Declaben
UNSPSC Description
15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1].
Target Antigen
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis;NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/15-deoxy-12-14-prostaglandin-a1.html
Solubility
10 mM in DMSO
Smiles
OC(CCCCCC[C@@H]1/C(C=CC1=O)=C\C=C\CCCCC)=O
Molecular Weight
318.45
References & Citations
[1]Zernecke A, et al. Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. FASEB J. 2003 Jun;17(9):1099-101.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118101/15-Deoxy-12-14-prostaglandin-A1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118101/
Clinical Information
No Development Reported
CAS Number
573951-20-9
Available Sizes
Curated Selection
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