15-Deoxy-Δ12,14-prostaglandin A1

15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1].

Product Specifications

CAS Number

[573951-20-9]

Product Name Alternative

SC-39026; Declaben

UNSPSC

12352211

Hazard Statement

H225-H319-H336

Target

Apoptosis; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/15-deoxy-12-14-prostaglandin-a1.html

Solubility

10 mM in DMSO

Smiles

OC(CCCCCC[C@@H]1/C(C=CC1=O)=C\C=C\CCCCC)=O

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Zernecke A, et al. Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. FASEB J. 2003 Jun;17 (9) :1099-101.