Apicidin
Product Specifications
UNSPSC Description
Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research[1][2][3][4].
Target Antigen
HDAC; Parasite
Type
Natural Products
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/apicidin.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(NC(C(N1[C@]2([H])CCCC1)=O)[C@@H](C)CC)[C@@H](NC([C@@H](NC2=O)CCCCCC(CC)=O)=O)CC3=CN(OC)C4=C3C=CC=C4
Molecular Weight
623.78
References & Citations
[1]Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000 Nov 1;60(21):6068-74.|[2]S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.|[3]Beom Soo Shin, et al. Quantitative determination of absorption and first-pass metabolism of apicidin, a potent histone deacetylase inhibitor. Drug Metab Dispos. 2014 Jun;42(6):974-82.|[4]Ahn MY, et al. HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. Oncol Lett. 2018 Nov;16(5):6552-6560.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6735/Apicidin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6735/Apicidin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
183506-66-3
Available Sizes
Curated Selection
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