NUC-7738
NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA) . NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer[1].
Product Specifications
CAS Number
2348493-39-8
UNSPSC
12352005
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nuc-7738.html
Purity
97.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(N[C@@H](C)C(OCC4=CC=CC=C4)=O)(OC5=CC=CC=C5)=O)C[C@H]3O
Molecular Formula
C26H29N6O7P
Molecular Weight
568.52
References & Citations
[1]Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65 (23) :15789-15804.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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