NUC-7738

NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA) . NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer[1].

Product Specifications

CAS Number

[2348493-39-8]

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nuc-7738.html

Purity

97.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(N[C@@H](C)C(OCC4=CC=CC=C4)=O)(OC5=CC=CC=C5)=O)C[C@H]3O

Molecular Formula

C26H29N6O7P

Molecular Weight

568.52

References & Citations

[1]Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65 (23) :15789-15804.