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ERCC1-XPF-IN-2

ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays[1].

Product Specifications

CAS Number

1808986-37-9

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ercc1-xpf-in-2.html

Purity

98.54

Solubility

DMSO : ≥ 250 mg/mL

Smiles

OC1=C(O)C=C(CNC(CC2=C(Cl)C=C(Cl)C=C2)=O)C=C1

Molecular Formula

C15H13Cl2NO3

Molecular Weight

326.17

References & Citations

[1]Chapman TM, et al. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25 (19) :4097-103.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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