AZD2098
AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research[1][2].
Product Specifications
CAS Number
566203-88-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AZD2098.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O
Molecular Formula
C11H9Cl2N3O3S
Molecular Weight
334.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Kindon N, et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 1;8 (9) :981-986.|[2]Asher Mullard. Cancer charity sees success re-prioritizing industry's shelved compounds. Nat Rev Drug Discov. 2014 May;13 (5) :319-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR4
Available Sizes
Frequently Asked Questions
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