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OTUB1/USP8-IN-1

Product Specifications

UNSPSC Description

OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer[1].

Target Antigen

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/otub1-usp8-in-1.html

Solubility

DMSO : 50 mg/mL (ultrasonic)|H2O : 4.07 mg/mL (ultrasonic;warming;adjust pH to 3 with 1 M HCL;heat to 60°C)

Smiles

O=C(C1=C2OC(C3=C(F)C=CC(O[C@H]4CN(C)CC4)=C3Cl)=N1)C5=C(C=CC=C5)C2=O

Molecular Weight

426.82

References & Citations

[1]Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-151563/OTUB1-USP8-IN-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-151563/OTUB1-USP8-IN-1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2858800-98-1

Available Sizes

Curated Selection

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