OTUB1/USP8-IN-1
OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer[1].
Product Specifications
CAS Number
[2858800-98-1]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/otub1-usp8-in-1.html
Purity
98.31
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 4.07 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)
Smiles
O=C(C1=C2OC(C3=C(F)C=CC(O[C@H]4CN(C)CC4)=C3Cl)=N1)C5=C(C=CC=C5)C2=O
Molecular Formula
C22H16ClFN2O4
Molecular Weight
426.82
References & Citations
[1]Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
Porcine Tumor Necrosis Factor Receptor Superfamily, Member 1A ELISA Kit
Porcine Tumor Necrosis Factor Receptor Superfamily, Member 1A ELISA Kit
Porcine Tumor Necrosis Factor Receptor Superfamily, Member 1A ELISA Kit