VU0357017 (hydrochloride)

VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM) . VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia[1][2][3].

Product Specifications

CAS Number

[1135242-13-5]

Product Name Alternative

CID-25010775

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/VU0357017-hydrochloride.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC.[H]Cl

Molecular Formula

C18H28ClN3O3

Molecular Weight

369.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Digby GJ, et al. Chemical modification of the M (1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. ACS Chem Neurosci. 2012 Dec 19;3 (12) :1025-36.|[2]Lebois EP, et al. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M (1) receptor function in the central nervous system. ACS Chem Neurosci. 2010;1 (2) :104-121.|[3]Digby GJ, et al. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. J Neurosci. 2012 Jun 20;32 (25) :8532-44.