LY134046

LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.

Product Specifications

CAS Number

[71274-97-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

N-myristoyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ly134046.html

Smiles

ClC1=C2C(CCCNC2)=CC=C1Cl

Molecular Formula

C10H11Cl2N

Molecular Weight

216.11

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Hahn RA, et al. Cardiovascular effects of LY134046, an inhibitor of norepinephrine N-methyltransferase, in spontaneously hypertensive rats. J Pharmacol Exp Ther. 1983 Jul;226 (1) :39-45.