Ethamsylate

Ethamsylate (Etamsylate) is an orally active anti-hemorrhagic compound. Ethamsylate inhibits biosynthesis and action of prostaglandins. Ethamsylate has the potential to maintain early hemostasis as well as restores capillary resistance. Ethamsylate acts as an antiangiogenic factor, inhibiting wound healing and matrigel tubulogenesis.[1][2][3].

Product Specifications

CAS Number

[2624-44-4]

Product Name Alternative

Etamsylate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Ethamsylate.html

Purity

99.49

Solubility

DMSO : 120 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(O)=CC=C1O)(O)=O.CCNCC

Molecular Formula

C10H17NO5S

Molecular Weight

263.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Zawrotniak M, et al. Selected mucolytic, anti-inflammatory and cardiovascular drugs change the ability of neutrophils to form extracellular traps (NETs) . Acta Biochim Pol. 2015;62 (3) :465-73.|[2]Kovács L, et al. Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro. Experientia. 1981 Nov 15;37 (11) :1182-3.|[3]Albiñana V, et al. Topically Applied Etamsylate: A New Orphan Drug for HHT-Derived Epistaxis (Antiangiogenesis through FGF Pathway Inhibition) . TH Open. 2019 Jul 26;3 (3) :e230-e243. |[4]Dolma S, et al. Ethamsylate Attenuates Mutilated Secondary Pathogenesis and Exhibits a Neuroprotective Role in Experimental Model of Spinal Cord Injury. Neuroscience. 2022 Feb 21;484:26-37.