PIKfyve-IN-1

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology[1]. PIKfyve-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2857982-26-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

PIKfyve

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/pikfyve-in-1.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

NC1=NC=C(CCC2)C(C3=C2NC4=C3C=C(C#CCN(C)C)C=C4)=N1

Molecular Formula

C20H21N5

Molecular Weight

331.41

Precautions

H302, H315, H318, H335

References & Citations

[1]David H Drewry, et al. Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. J Med Chem