DBET1

DBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+) -JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker[1].

Product Specifications

CAS Number

[1799711-21-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dBET1.html

Purity

99.56

Solubility

DMSO : 43.33 mg/mL (ultrasonic)

Smiles

O=C(NCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4

Molecular Formula

C38H37ClN8O7S

Molecular Weight

785.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348 (6241) :1376-81.