(-) -Dihydroguaiaretic acid

(-) -Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-) -Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-) -Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells) [1][2].

Product Specifications

CAS Number

[124649-78-1]

UNSPSC

12352005

Target

Lipoxygenase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/minus-dihydroguaiaretic-acid.html

Purity

98.79

Solubility

10 mM in DMSO

Smiles

COC(C=C1C[C@@H](C)[C@H](C)CC2=CC(OC)=C(C=C2)O)=C(C=C1)O

Molecular Formula

C20H26O4

Molecular Weight

330.42

References & Citations

[1]Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72 (11) :2981-6. |[2]Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17 (3) : 1387-1392.