Imazalil

Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].

Product Specifications

CAS Number

[35554-44-0]

Product Name Alternative

Enilconazole

UNSPSC

12352005

Hazard Statement

H301, H318, H332, H410

Target

Fungal; Pregnane X Receptor (PXR)

Type

Natural Products

Related Pathways

Anti-infection; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Imazalil.html

Purity

99.54

Solubility

DMSO : ≥ 100 mg/mL|H2O : 20 mg/mL (ultrasonic)

Smiles

C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2

Molecular Formula

C14H14Cl2N2O

Molecular Weight

297.18

Precautions

H301, H318, H332, H410

References & Citations

[1]Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259 (3) :338-45.|[2]Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43 (7) :443-450.|[3]Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33 (6) :650-658.