Vapreotide (acetate)

Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.

Product Specifications

CAS Number

[849479-74-9]

Product Name Alternative

RC-160 (acetate) ; BMY-41606 (acetate)

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Vapreotide__acetate_.html

Purity

99.85

Solubility

H2O : 14.29 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCCN)=O)C(C)C)=O)C(N[C@H](C(N)=O)CC2=CNC3=CC=CC=C23)=O)NC([C@H](N)CC4=CC=CC=C4)=O)=O)CC5=CC=C(C=C5)O)N[C@@H]1CC6=CNC7=CC=CC=C67.CC(O)=O

Molecular Formula

C59H74N12O11S2

Molecular Weight

1191.42

References & Citations

[1]Spitsin S, et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20 (5) :247-55.|[2]Hofland LJ, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on theinhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology. 1994 Jan;134 (1) :301-6.|[3]Buscail L, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci U S A. 1995 Feb 28;92 (5) :1580-4.|[4]Veal N, et al. Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis. Dig Dis Sci. 2003 Jan;48 (1) :154-61.|[5]Pinski J, et al. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.