1G244

1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[1][2].

Product Specifications

CAS Number

[847928-32-9]

Product Name Alternative

tert-Butylhydroquinone

UNSPSC

12352005

Target

Apoptosis; Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1g244.html

Purity

98.50

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=C(C=CC=C2)C1)[C@@H](N)CC(N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O

Molecular Formula

C29H30F2N4O2

Molecular Weight

504.57

References & Citations

[1]Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9 (1) :18094.|[2]Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.