Tivanisiran
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) mRNA[1].
Product Specifications
CAS Number
[1848224-71-4]
Product Name Alternative
SYL1001
UNSPSC
12352208
Target
Small Interfering RNA (siRNA) ; TRP Channel
Type
Oligonucleotides
Related Pathways
Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tivanisiran.html
Purity
97.48
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Tivanisiran]
Molecular Weight
12068.30 (AS: 5294.6 + SS: 6125.7)
References & Citations
[1]Anne-Marie Bleau, et al. Development of tivanisiran, a topical siRNA designed to|[2]Javier Moreno-Montañés, et al. Tivanisiran, a novel siRNA for the treatment of dry eye disease. Expert Opin Investig Drugs. 2018 Apr;27 (4) :421-426.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Curated Selection
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