ZEN-3219
ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4 (BD1), BRD4 (BD2) and BRD4 (BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4[1].
Product Specifications
CAS Number
[1952264-34-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zen-3219.html
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C=CC(C1=C(C)ON=C1C)=C2)N2CC3=CC=C(C4OC4)C=C3
Molecular Formula
C19H18N2O3
Molecular Weight
322.36
References & Citations
[1]Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61 (18) :8202-8211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Curated Selection
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