SM-360320

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

Product Specifications

CAS Number

[226907-52-4]

Product Name Alternative

CL-087

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/sm-360320.html

Purity

99.41

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1

Molecular Formula

C15H17N5O3

Molecular Weight

315.33

References & Citations

[1]Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16 (5) :462-472. |[2]Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103 (6) :1828-1833.