Resomelagon (acetate)

Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research[1][2].

Product Specifications

CAS Number

[1809420-72-1]

Product Name Alternative

AP1189 (acetate)

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/resomelagon-acetate.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(N)N/N=C/C=C/C1=CC=CN1C2=C(C=CC=C2)[N+]([O-])=O.CC(O)=O

Molecular Formula

C16H18N6O4

Molecular Weight

358.35

References & Citations

[1]Montero-Melendez T, et, al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194 (7) :3381-8.|[2]WHO Drug Information. International Nonproprietary Names for Pharmaceutical.