PLX7922
PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].
Product Specifications
CAS Number
1638772-61-8
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plx7922.html
Purity
98.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1=C(F)C(C2=C(C3=CC=NC(N)=N3)SC(C(C)(C)C)=N2)=CC=C1)(N(CC)C)=O
Molecular Formula
C20H25FN6O2S2
Molecular Weight
464.58
References & Citations
[1]Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526 (7574) :583-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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