Censavudine

Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1, respectively[1][2]. Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[634907-30-5]

Product Name Alternative

Festinavir; BMS-986001; OBP-601

UNSPSC

12352005

Hazard Statement

H341, H373

Target

HIV; Nucleoside Antimetabolite/Analog; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/censavudine.html

Purity

98.71

Solubility

DMSO : 52 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C#C[C@@]1(O[C@](N(C=C2C)C(NC2=O)=O)([H])C=C1)CO

Molecular Formula

C12H12N2O4

Molecular Weight

248.24

Precautions

H341, H373

References & Citations

[1] Robert A Smith, et al. The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity Against HIV-2 Than Against HIV-1. Antimicrob Agents Chemother. 2015 Dec;59 (12) :7437-46.|[2]Long Yuan, et al. Dried Blood Spot Analysis Without Dilution: Application to the LC-MS/MS Determination of BMS-986001 in Rat Dried Blood Spot. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:201-9.