(R) -Zanubrutinib-d5
(R) -Zanubrutinib-d5 is deuterium labeled (R) -Zanubrutinib. (R) -Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.
Product Specifications
UNSPSC
12352005
Target
Btk; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2NCC[C@H](C3CCN(C(C=C)=O)CC3)N2N=C1C4=CC=C(OC5=C([2H])C([2H])=C([2H])C([2H])=C5[2H])C=C4)N
Molecular Formula
C27H24D5N5O3
Molecular Weight
476.58
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Wu J, et al. Acalabrutinib (ACP-196) : a selective second-generation BTK inhibitor. J Hematol Oncol. 2016 Mar 9;9:21.|[3]Wu J, et al. Second-generation inhibitors of Bruton tyrosine kinase. J Hematol Oncol. 2016 Sep 2;9 (1) :80.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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