C-Dim 12
Displays neuroprotective activity in a mouse model of progressive neurodegeneration
Product Specifications
Background
C-DIM 12 is a nurr1 activator that inhibits bladder cancer growth (1,2). It also inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters (3). It displays neuroprotective activity in a mouse Parkinson's disease models (4).
Product Name Alternative
3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
UNSPSC
41116105
Source
Synthetic
Purity
>98% (TLC); NMR (Conforms)
Weight
0.005
Format
Orange powder
Solubility
May be dissolved in DMSO (35 mg/ml); or ethanol (35 mg/ml)
Molecular Formula
C23H17ClN2
Molecular Weight
356.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1.Inamoto T., et al. (2008) Mol. Cancer Ther. 7:3825
2.Li X., et al. (2012) Biochem. Pharmacol. 83:1445
3.De Miranda B.R.,et al. (2015) Mol. Pharmacol. 87:1021
4.De Miranda B.R., et al. (2013) J. Pharmacol. Exp. Ther. 345:125
CAS Number
178946-89-9
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