DS-7423
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].
Product Specifications
CAS Number
1222104-37-1
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds-7423.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1[C@H](C)CN(C2=NC3=C(N4CCOCC4)N=C(C5=CN=C(N)N=C5)N=C3N2CC(F)(F)F)CC1)=O
Molecular Formula
C22H27F3N10O2
Molecular Weight
520.51
References & Citations
[1]Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42 (7) :757-62.|[2]Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9 (2) :e87220.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3881304 1.0 µg DNA
Plcg1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details MBS1415652-01 0.02 mg (E-Coli)
Recombinant Pseudomonas syringae pv. phaseolicola Nicotinate phosphoribosyltransferase (pncB)
Sign In for Pricing
View Details MBS1415652-02 0.02 mg (Yeast)
Recombinant Pseudomonas syringae pv. phaseolicola Nicotinate phosphoribosyltransferase (pncB)
Sign In for Pricing
View Details MBS1415652-03 0.1 mg (E-Coli)
Recombinant Pseudomonas syringae pv. phaseolicola Nicotinate phosphoribosyltransferase (pncB)
Sign In for Pricing
View Details