RBP4 inhibitor 1
RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice[1].
Product Specifications
CAS Number
1198180-03-8
UNSPSC
12352005
Target
Lipocalin Family
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rbp4-inhibitor-1.html
Purity
99.74
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CO[C@@H]1CN(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC1
Molecular Formula
C14H13F6NO3
Molecular Weight
357.25
References & Citations
[1]Shinji Nakamura, et al. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers. Bioorg Med Chem. 2022 Jan 15;54:116553.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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