Sonepiprazole (hydrochloride)
Sonepiprazole (PNU-101387G) hydrochloride is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively[1].
Product Specifications
CAS Number
170857-36-0
Product Name Alternative
PNU-101387G (hydrochloride) ; U-101387G (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sonepiprazole-hydrochloride.html
Smiles
O=S(C1=CC=C(N2CCN(CC[C@H]3C4=CC=CC=C4CCO3)CC2)C=C1)(N)=O.Cl
Molecular Formula
C21H28ClN3O3S
Molecular Weight
437.98
Precautions
P261-P280-P302+P352
References & Citations
[1]Mark H Corrigan, et al. Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial. Biol Psychiatry. 2004 Mar 1;55 (5) :445-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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