Sonepiprazole (hydrochloride)

Sonepiprazole (PNU-101387G) hydrochloride is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively[1].

Product Specifications

CAS Number

[170857-36-0]

Product Name Alternative

PNU-101387G (hydrochloride) ; U-101387G (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sonepiprazole-hydrochloride.html

Smiles

O=S(C1=CC=C(N2CCN(CC[C@H]3C4=CC=CC=C4CCO3)CC2)C=C1)(N)=O.Cl

Molecular Formula

C21H28ClN3O3S

Molecular Weight

437.98

Precautions

P261-P280-P302+P352

References & Citations

[1]Mark H Corrigan, et al. Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial. Biol Psychiatry. 2004 Mar 1;55 (5) :445-51.