MRT-14
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling[1].
Product Specifications
CAS Number
1263131-83-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrt-14.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1)NC2=CC=CC(NC(NC(C3=CC(OC)=C(C(OC)=C3)OC)=O)=N)=C2
Molecular Formula
C24H24N4O5
Molecular Weight
448.47
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78 (4) :658-665.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
244156-ML550 100 µL
CAGE1 (Cancer antigen 1, CTAG3, FLJ40441, bA69L16.7) (MaxLight 550)
Sign In for Pricing
View Details 
GTR15236473 1 Vial
Lentiviral mouse Hoxd1 shRNA (UAS) - Lentiviral mouse Hoxd1 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details ![Methyl 2'-formyl[1,1'-biphenyl]-3-carboxylate](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
