SRI-37330

SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1].

Product Specifications

CAS Number

[2322245-42-9]

UNSPSC

12352005

Target

Arrestin

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sri-37330.html

Concentration

10mM

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CS(=O)(NCC1CN(C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)CCC1)=O

Molecular Formula

C16H19F3N4O2S

Molecular Weight

388.41

References & Citations

[1]Thielen LA, et al. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32 (3) :353-365.e8.