Hydroxybupropion

Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6. Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonist[1] .

Product Specifications

CAS Number

[92264-81-8]

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Adrenergic Receptor; Drug Metabolite; nAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydroxybupropion.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NC(C)(C)CO)C(C1=CC=CC(Cl)=C1)=O

Molecular Formula

C13H18ClNO2

Molecular Weight

255.74

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Damaj MI, et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66 (3) :675-82.