Colchiceine

Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569) . Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis[1][2][3].

Product Specifications

CAS Number

[477-27-0]

Product Name Alternative

O10-Demethylcolchicine

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/colchiceine.html

Purity

98.1

Solubility

10 mM in DMSO

Smiles

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(O)C2=O)=O

Molecular Formula

C21H23NO6

Molecular Weight

385.41

Precautions

H302, H315, H318, H335

References & Citations

[1]Rodríguez L, et al. Effects of colchicine and colchiceine in a biochemical model of liver injury and fibrosis. Arch Med Res. 1998;29 (2) :109-116.|[2]Edström A, et al. Inhibition of fast axonal transport and microtubule polymerization in vitro by colchicine and colchiceine. Acta Physiol Scand. 1979;107 (3) :233-237.|[3]Nava-Ocampo AA, et al. Effect of colchiceine and ursodeoxycholic acid on hepatocyte and erythrocyte membranes and liver histology in experimentally induced carbon tetrachloride cirrhosis in rats. Eur J Clin Invest. 1997;27 (1) :77-84.