ZCL278
ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC) [1][2][3][4].
Product Specifications
CAS Number
587841-73-4
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Arenavirus; Dengue Virus; Ras; VSV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ZCL278.html
Purity
98.49
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC(NC1=CC=C(S(=O)(NC2=NC(C)=CC(C)=N2)=O)C=C1)=S)COC3=CC=C(Br)C=C3Cl
Molecular Formula
C21H19BrClN5O4S2
Molecular Weight
584.89
Precautions
H302, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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