What is the catalog number for ZCL278?

The catalog number for ZCL278 is HY-13963.

What sizes are available for ZCL278?

ZCL278 is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg.

How many pack sizes does ZCL278 come in?

ZCL278 is available in 5 different pack sizes.

ZCL278 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ZCL278?

ZCL278 is manufactured by QuantiMol.

What is the estimated delivery time for ZCL278?

Estimated delivery time for ZCL278 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ZCL278?

The safety data sheet for ZCL278 is available here: http://file.medchemexpress.com/batch_PDF/HY-13963/ZCL278-SDS-MedChemExpress.pdf.

ZCL278

ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC) [1][2][3][4].

Product Specifications

CAS Number

587841-73-4

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Arenavirus; Dengue Virus; Ras; VSV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ZCL278.html

Purity

98.49

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC(NC1=CC=C(S(=O)(NC2=NC(C)=CC(C)=N2)=O)C=C1)=S)COC3=CC=C(Br)C=C3Cl

Molecular Formula

C21H19BrClN5O4S2

Molecular Weight

584.89

Precautions

H302, H410

References & Citations

[1]Friesland A, et al. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A. 2013 Jan 22;110 (4) :1261-6.|[2]Chou YY, et al. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 Apr 14;90 (9) :4494-510.|[3]An Y, Liu T, Liu X, Zhao L, Wang J. Rac1 and Cdc42 Play Important Roles in Arsenic Neurotoxicity in Primary Cultured Rat Cerebellar Astrocytes. Biol Trace Elem Res. 2016 Mar;170 (1) :173-82. |[4]Liang B, et al. Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer. Cancer Lett. 2024 Apr 10;587:216702.