Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Paprotrain

Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Paprotrain.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL

Smiles

N#C/C(C1=CNC2=CC=CC=C21)=C\C3=CN=CC=C3

Molecular Formula

C16H11N3

Molecular Weight

245.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Labrière C, et al. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:920-934.|[2]Liu J, et al. MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol. 2013 Dec 21;11:117.|[3]Zhang Y, et al. KIF20A regulates porcine oocyte maturation and early embryo development.|[4]Tcherniuk S, et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl. 2010 Oct 25;49 (44) :8228-31.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101298/Paprotrain-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101298/Paprotrain-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Kinesin-6

CAS Number

[57046-73-8]

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human DMRTB1 Protein Lysate
MBS8410587-01 0.02 mg

Human DMRTB1 Protein Lysate

Ask
View Details
Human DMRTB1 Protein Lysate
MBS8410587-02 5x 0.02 mg

Human DMRTB1 Protein Lysate

Ask
View Details
MFluor™ Violet 540 Anti-non-human primates/ human CD157 Antibody *SY11B5*
11570121-AAT 500 Tests

MFluor™ Violet 540 Anti-non-human primates/ human CD157 Antibody *SY11B5*

Ask
View Details
BCL2L12 Rabbit mAb
MBS9147481-01 0.02 mL

BCL2L12 Rabbit mAb

Ask
View Details
BCL2L12 Rabbit mAb
MBS9147481-02 0.1 mL

BCL2L12 Rabbit mAb

Ask
View Details
BCL2L12 Rabbit mAb
MBS9147481-03 5x 0.1 mL

BCL2L12 Rabbit mAb

Ask
View Details