Paprotrain
Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
Product Specifications
CAS Number
57046-73-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Paprotrain.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#C/C(C1=CNC2=CC=CC=C21)=C\C3=CN=CC=C3
Molecular Formula
C16H11N3
Molecular Weight
245.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Labrière C, et al. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:920-934.|[2]Liu J, et al. MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol. 2013 Dec 21;11:117.|[3]Zhang Y, et al. KIF20A regulates porcine oocyte maturation and early embryo development.|[4]Tcherniuk S, et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl. 2010 Oct 25;49 (44) :8228-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-6
Available Sizes
Frequently Asked Questions
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