Manidipine (dihydrochloride)

Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection[1][2][3][4][5][6].

Product Specifications

CAS Number

[89226-75-5]

Product Name Alternative

CV-4093

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; NF-κB

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/manidipine-dihydrochloride.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3.[H]Cl.[H]Cl

Molecular Formula

C35H40Cl2N4O6

Molecular Weight

683.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Roca-Cusachs A, et al. Antihypertensive effect of manidipine. Drugs. Drugs. 2005, 65, 11-19.|[2]Cavalieri L, , et al. Metabolic effects of manidipine. Am J Cardiovasc Drugs. 2009, 9, 3.|[3]Franco Bernini, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010, 62, 3.|[4]Urata S, et al. Calcium Influx Regulates the Replication of Several Negative-Strand RNA Viruses Including Severe Fever with Thrombocytopenia Syndrome Virus. J Virol. 2023, 97, 3.|[5]Wang S, et al. Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection. J Virol. 2017, 91, 21.|[6]Tohse N, et al. Voltage-dependent modulation of L-type Ca2+ current by manidipine in guinea-pig heart cells. Eur J Pharmacol. 1993, 249 (2) :231-3.|[7]Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Pharmacol Res. 2010Jpn Circ J. 1998, 62 (1) :47-52.